623 Microneedling with autologous platelet-rich plasma verses microneedling with topical insulin in the treatment of post-acne atrophic scars: a simultaneous split-face comparative study

Post-acne atrophic scars (PAS) are common sequelae of acne. Peels, platelet rich plasma (PRP), subcision, dermabrasion, lasers etc. useful in PAS; however, many them associated with major adverse effects (AE). We conducted a split-face comparative study microneedling PRP (Left side) and topical insulin (TI) (Right for PAS. Sixteen patients PAS were enrolled after taking written consent. Exclusion criteria included presence active acne and/or infections over face, pregnancy or lactation, on isotretinoin, history keloidal tendency, bleeding disorders deranged blood sugar levels. Under antiseptic measures anaesthesia, (using dermaroller 1.5 mm length 192 needles roller drum) was performed standard manner both side the face. On right 1-2ml TI (Human actrapid 40IU/ml® solution) applied, while left autologous applied. Ice pack applied treated areas face cleaned 30min. Patients advised to follow photoprotection. All received such 4 sittings at monthly interval followed till 3 months post last sitting. Qualitative Global Acne Scarring System used compare treatment-associated improvement. Of 16 patients, 14 completed study. Right showed 45.73% improvement, 26.44% improvement “Paired t-test” significant both, (t =12.20, p=0.01) =2.67, p=0.03). Icepick boxcar responded better therapy. AE transient erythema (n=8), pain (n=6) edema (n=3). Both, PRP, combined may achieve comparable advantageous safety profile However, readily accessibility, low cost, non-invasive nature merits use PRP.